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2007 09/01/2007 08/31/2008 59-0735717 HOWARD HUGHES MEDICAL INSTITUTE

4000 JONES BRIDGE ROAD CHEVY CHASE MD USA 20815-6789 301-215-8500

hhmi.org 03 A 445362364266 Y N N

1688476 650208882 2277690 2042238 235452 640241285 444055744425 8637682 443156611129 899133296 8637682 907770978 3565826 2203710899 700683267 173220834 873904101 1329806798 18633041477 -2547408223 17415440052 Y 113925950 8441456 258690 209588341 18057566 34565367 13779164 678639 5064110 118049026 2934263 571210 81563185 15567227 4357581 6295759 2785019 19490761 77762285 873904101 N Conduct of medical research for the benefit of mankind 700683267 Description of medical research program see below Quality medical research organization expenditures for the year were 681,222,346. The Howard Hughes Medical Institute or HHMI is the nations largest medical research organization MRO, with spending in the direct, active conduct of medical research in conjunction with hospitals during its 2008 fiscal year of spending for exempt purposes in 2008 of 880,625,452. 575768211 Other Philanthropic Activities of the Howard Hughes Medical Institute - HHMIs office of graduate, undergraduate, and precollege education in the life sciences. With aggregate grant awards of more than 1.6 billion since 1987, HHMI is the largest private funder of science education in the United States. During the fiscal year, the Institute distributed 84 million in grants to support science education and international research. 124915056 101021147 192081657 2275545 1410914 10936171928 8699283431 8426569596 9581100225 15104310 5041936 10713671 10062374 1440597232 614723796 785424214 825873436 1414065355 2308723690 21676241456 21618535727 201925582 218775478 158455724 176621878 576500000 660000000 49765630 40376000 2056553043 3107322319 3043199979 4203095675 18633041477 17415440052 18633041477 17415440052 21676241456 21618535727 10 N N Y Thomas R Cech PhD Chevy Chase MD USA 20815 040.00 1094500 222818 Craig A Alexander Esq Chevy Chase MD USA 20815 040.00 449700 96245 Peter J Bruns PhD Chevy Chase MD USA 20815 040.00 437800 107916 David A Clayton PhD Chevy Chase MD USA 20815 040.00 536300 118056 Joseph D Collins Chevy Chase MD USA 20815 040.00 292400 74952 Jack E Dixon PhD Chevy Chase MD USA 20815 040.00 587328 125719 Avice A Meehan Chevy Chase MD USA 20815 040.00 351664 79763 Edward J Palmerino Chevy Chase MD USA 20815 040.00 291900 79151 Gerald M Rubin PhD Chevy Chase MD USA 20815 040.00 596520 130127 Landis Zimmerman Chevy Chase MD USA 20815 040.00 1222910 110471 Robert C Mullins Chevy Chase MD USA 20815 040.00 190400 60579 Heidi E Henning Esq Chevy Chase MD USA 20815 040.00 290600 57086 Marion M Howard Chevy Chase MD USA 20815 040.00 154668 33962 Susan S Plotnick Chevy Chase MD USA 20815 040.00 171387 67784 James A Baker III Esq Chevy Chase MD USA 20815 002.00 40000 Charlene Barshefsky Chevy Chase MD USA 20815 002.00 20000 Richard G Darman Chevy Chase MD USA 20815 002.00 25000 Joseph L Goldstein MD Chevy Chase MD USA 20815 002.00 51250 Hanna H Gray PhD Chevy Chase MD USA 20815 006.00 60000 Garnett L Keith Chevy Chase MD USA 20815 002.00 50000 Jeremy R Knowles D Phil Chevy Chase MD USA 20815 002.00 37500 Paul M Nurse PhD Chevy Chase MD USA 20815 002.00 40000 Kurt L Schmoke Esq Chevy Chase MD USA 20815 002.00 45000 Anne M Tatlock Chevy Chase MD USA 20815 002.00 40000 Joan S Leonard Esq Chevy Chase MD USA 20815 0 216300 42390 0 N N Y Y N N N N Y Y N N Y Y N N N OR OK NY MD MA IN IL CA AZ AK 2636 Y Y Y N N Y HHMI Real Estate Inc Chevy Chase MD USA 20815 20-3967202 Capital Calls 44206000 Leland Hughes Investment Fund LLC Chevy Chase MD USA 20815 06-1746533 Capital Calls 0 NU Hughes Investment Fund LLC Chevy Chase MD USA 20815 26-0422313 Capital Calls 0 Y HHMI Real Estate Inc Chevy Chase MD USA 20815 20-3967202 Dividends 4171807 N

001332 Robert J Kolyer Jr Chevy Chase MD USA 20815 040.00 837058 79174 0 Richard A Pender Chevy Chase MD USA 20815 040.00 701553 91022 0 Mark A Barnard Chevy Chase MD USA 20815 040.00 647018 73637 0 Anil Madhok Chevy Chase MD USA 20815 040.00 618989 51379 0 Matthew R Lee Chevy Chase MD USA 20815 040.00 600475 66483 0 000086 Southeasten Asset Mgt Inc Via Spru Memphis TN USA 38119 Investment Management 5515708 BNY Mellon Bank Pittsburgh PA USA 15258 Investment Custodian 3889266 Fortress Investment Group New York NY USA 10105 Investment Management 2856150 WS Capital Management Advisor to HH Dallas TX USA 75201 Investment Management 2830554 Numeric Investors LLC Via HHMI XII Boston MA USA 02210 Investment Management 2639417 83 Clark Construction Group LLC Bethesda MD USA 20814 Construction 10308433 Aramark Harrison Lodging Aramark Ser Philadelphia PA USA 19107 Conference Center Ma 2522703 Tandemseven Inc Plymouth MA USA 02360 Portal Consulting-IT 1243164 Lawrence Berkeley Nat'l Laboratory Berkeley CA USA 94720 Beamline 746410 Fisher Scientific Company LLC Pittsburgh PA USA 15275 Supply Room Management 518328 1949 Y Y N Y Y N Y Y N N Y 0 0 1949